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Recent developments in technology have presented viable dosage alternatives for patients who may have difficulty swallowing tablets. Traditional tablets and capsules may be inconvenient or impractical for some patients. Geriatric and pediatric patients experience difficulty in swallowing conventional tablets which leads to poor patience compliance. This problem is overcomed with use of drug delivery system known as orally disintegrating tablets. These are novel types of tablets which disintegrate/dissolve/disperse in saliva for 60 seconds or less (1, 2, 3). They are also suitable for the mentally ill, the bedridden and patients who do not have easy access to water. The benefits in terms of patience compliance, rapid onset of action, possibility for increased bioavailability, and good stability make these tablets popular as a dosage form of choice in the current market (2). Orally disintegrating tablets are suitable formulation for all active substances which can be orally administered (3). A pharmaceutical formulation is composed of several composition factors and process variables. These factors and variables not only affect the characteristic property of the dosage form but also make it difficult to formulate. Formulation experience with pharmaceutical preparation generally can guide a formulation expert to select those variables that most likely have an effect on those corresponding responses (4). Traditional formulation designs were based on trial and error. It is time-consuming, unreliable, costly and often unsuccessful. The rapid development of statistical experimental designs, optimisation techniques and computer technologies provide an effective method for modelling Macedonian pharmaceutical bulletin, 51, (1,2) 15-22 (2005) ISSN 1409 8695 UDC: 615.214.24.014

Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology