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Phenobarbital is utilized in the treatment of a wide range of seizures, except for nonattendance seizures. It is no less powerful at seizure control than phenytoin, anyway phenobarbital isn't also endured. Phenobarbital may give a clinical favorable position over carbamazepine for rewarding fractional beginning seizures. Carbamazepine may give a clinical bit of leeway over phenobarbital for summed up beginning tonic-clonic seizures. It’s extremely long dynamic half-life (53–118 hours) implies for certain individual’s dosages don't need to be taken each day, especially once the portion has been settled over a time of a little while or months, and seizures are adequately controlled. The main line drugs for treatment of status epilepticus are benzodiazepines, for example, lorazepam or diazepam. In the event that these fizzles, at that point phenytoin might be utilized, with phenobarbital being an option in the US, yet utilized just third line in the UK. Bombing that, the main treatment is sedation in escalated care.

Comparative Efficacy of Phenobarbitone versus levetiracetam in the initial treatment of neonatal seizure