English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Ischemic heart disease is the interruption of blood supply to the heart causes several\udbiochemical alterations which may lead to cardiac dysfunction and ultimately cell death. Medicinal\udplants and plant based foods such as peanut (Arachishypogaea L.) have received great attention for their\udsalutary effects and potential to treat many aspects of ischemic heart disease due to their antioxidant\udproperty. Objective: To observe the effects of peanut (Arachishypogaea L.) and its combination with\udpropranolol in isoproterenol induced myocardial damage in rats. Method: This experimental study was\udcarried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka in 2012.\udFor this purpose, 20 Wistar albino rats, age 85 to 100 days, weighing 120 to 150g (initial body weight)\udwere included in the peanut treated group.They were sub-divided into CT-P (Cardiotoxic group with\udisoproterenol after peanut treatment) and CT-C (Cardiotoxic group with isoproterenol after combined\udtreatment of peanut and propranolol). Age and weight matched 30 Wistar albino rats without any peanut\udsupplementation were taken and sub-divided into three sub-groups, BC (Baseline control), CT\ud(Cardiotoxic group with isoproterenol) and CT-PRO (Cardiotoxic group with isoproterenol after\udpropranolol treatment). Each sub-group consisted of 10 rats. After taking final body weight all the rats\udwere sacrificed on 22nd day. Blood was collected from heart & supernatant serum was preserved in deep\udfreeze until analysis. For assessment of myocardial damage, some cardiac biomarker enzymes, like\udserum CK-MB & LDH were estimated by using immunoassay method. The statistical analysis was done\udby one way ANOVA and Bonferroni test as applicable. Result: In this study, percent change from initial\udbody weight to final body weight was significantly (p<0.01) lower both in CT-P and CT-C as compared\udto that of BC. Again, the mean serum CK-MB and LDH levels were significantly (p<0.01) higher in CT,\udCT-PRO, CT-P & CT-C in comparison to that of BC. On the other hand, the serum CK-MB and LDH\udlevels were lower in CT-PRO, CT-P and CT-C when compared to that of CT though the differences were\udstatistically significant (p<0.01, p<0.05) in case of CT-PRO and CT-C but not significant in case of CTP.\udAgain, the values were also significantly lower in CT-C (p<0.01,p<0.05) as compared to that of CTP.\udConclusion: The present study revealed that peanut can lower serum CK-MB & LDH levels towards\udnormal in isoproterenol induced myocardial damaged rats. However, the combined therapy of peanut\udwith propranolol showed synergistic effect on lowering serum CK-MB & LDH levels.\u

Effects of Peanut (Arachis Hypogaea L.) and Its Combination with Propranolol in Isoproterenol Induced Myocardial Damage in Rats