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Throughout the annals of time, men even the prehistoric ones have been fascinated by the everexisting rhythmic processes in living systems. However, this idea wasn’t completely in the open till 1797 when Hufeland proposed rhythmic events of life in relation to 24 hours or solar day as a prime unit of functional chronology1. In Florida, nose and throat surgeons found that hemorrhages in throat operation were 82% higher during the second quarter of the cycle of the moon than at other times2. Similarly, insulin sensitivity index was found to be lower during winter than summer in Swedish population3. Seasonal variations of HbA1C in diabetic subjects and glycemic variations in healthy subjects have also been reported4-6. Thus, it seems that periodic biological events are intimately related to the non-biological cycles, whether terrestrial, astronomical, physical, electrical or others. But certainly it has been realized by the early scientists that the universe is rhythmic and displays incessant movement in the form of periodicity. The capacity to follow them, to oscillate, would enhance the survival potential of a species, including we, the human beings.

Calcium Oscillations and its Functional Siognificance in Chronobiology of Pancreatic Î²-Cells: The Art of Discovering Science