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Two benzimidazole derivatives namely 2-methyl-1H-benzimidazole (1) and 1H-benzimidazol-2- ylmethanol (2) were synthesized in high yields by condensing O -phenylenediamine with two different carboxylic acid derivatives: glacial acetic acid and glycolic acid, following a different synthetic protocol. Structures were elucidated by spectroscopic methods. Among the two benzimidazole derivatives synthesized, 2-methyl-1Hbenzimidazole (1) showed moderate antioxidant activity with IC 50 values of 144.84μg/ml whereas 1H-benzimidazol- 2-ylmethanol (2) displayed mild antioxidant activity (IC 50 value 400.42 μg/ml). Compound 1 also exhibited prominent cytotoxic activities with the LC 50 value of 0.42 μg/ml when compared to the standard vincristine sulphate (LC 50 value of 0.544 μg/ ml). It also demonstrated weak antimicrobial activity having 7-8 mm of zone of inhibition. Dhaka Univ. J. Pharm. Sci. 15(1): 83-87, 2016 (June)

Synthesis and Biological Evaluation of 2-methyl-1Hbenzimidazole and 1H-benzimidazol-2-yl-methanol