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2,4-Dichloro pyrimidine-6-carbonylchloride (2) was synthesized by refluxing uracil-6-carboxylic acid (orotic acid) with phosphorus oxychloride and phosphorus pentachloride. Compound (2) underwent a smooth coupling reaction with a number of substituted arylamines to yield 2, 4-dichloro-6-amidopyrimidines (8-12) which were converted to the corresponding 2, 4-dimethoxy-6-amidopyrimidines (13-17) on treatment with sodium methoxide in methanol. Compounds 13-17 afforded 6-amido-(1H, 3H)-pyrimidine-2, 4-diones (18-22) in good yield on refluxing with 6 M hydrochloric acid. These pyrimidinone derivatives may exhibit antiviral actitities. Key word: Pyrimidine, uracil, orotic acid, phosphorus oxychloride, arylamines, antiviral INTRODUCTION The importance of 5-substituted derivatives of uracil as anticancer and antiviral agents is wellestablished. 5-Fluorouracil (5-FU) I and the corresponding 2-deoxyribonucleoside (FUdR) are being used as anticancer agents whereas 5-iodo-2deoxyuridine is of importance as an antiviral agent. Dihydroalkoxybenzyloxopyrimidines (DABOs) II are a new class of specific inhibitors of human immunodeficiency virus type 1 (HIV-1) which possess a benzyl moiety and an alkyl (cycloalkyl) chain linked through an oxygen bridge to the uracil or thymine base. Replacement of the side chain oxygen with sulfur atom furnished thio-DABOs, which showed increased anti-HIV activity. Miyasaka et al have reported that 1-[(2-hydroxyethoxy) methyl]-6-phenylthio) thymine (HEPT) III has potent and selective in vitro activity against HIV-1. Correspondence to: Md. Wahab Khan E mail: mwkhan@chem.buet.ac.bd Dhaka Univ. J. Pharm. Sci. 13(1): 27-29, 2014 (June) NH

An expeditious synthesis of 6-Amido-(1H,3H)-Pyrimidine- 2,4-Diones from Uracil-6-Carboxylic Acid