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To elucidate the factors that induce phase transitions in biomembranes due to interactions of proteins/peptides at the lipid membrane-interface, the effects of positively charged peptides on the cubic phase (Q 229 ) of Dioleoylphosphatidylglycerol (DOPG)/Monoolein (MO) membranes were investigated. Small angle X-ray Scattering (SAXS) results revealed that 12 mol% DOPG/88 mol % MO membranes in excess water at 25°C is body centered cubic phase of crystallographic space group Im3m (Q 229 ). In presence of peptide LLKKK, the lattices constant of Q 229 phase was gradually decreased with an increase of peptide concentration and a phase transition from cubic (Q 229 ) to cubic (Q 224 ) phase occurred at R=0.080; (R= molar ratio of peptide to lipid). On the other hand the designed peptide WLFLLKKK and antimicrobial peptide Magainin-2 induced lamellar phase (L α ) in the same mixture membranes. These results indicate that the interactions of the these peptides with this mixture membrane are different: LLKKK induces electrostatic attractive interactions and that of WLFLLKKKK and Magainin-2 bound with the lipid membranes induce electrostatic repulsive interaction at the membrane-interface, might be the major factor inducing different phase transitions in 12 mol% DOPG/88mol% MO mixture membranes. Key words: Antimicrobial peptide Magain-2; Dioleoylphosphatidylglycerol; Monoolein; Cubic phases; Small angle X-ray Scattering DOI: 10.3329/bjsir.v45i3.6530 Bangladesh J. Sci. Ind. Res. 45(3), 219-224, 2010

bangladesh journal of scientific and industrial research

Phase Transition in Di-oleoylphosphatidylglycerol/Monoolein Membranes due to Interactions of Positively Charged Peptides at their Lipid Membrane-Interface