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Inhibition of some carbohydrate metabolizing enzymes is one of the modes of\udaction of antihyperglycemic agents. The aim of this study was to investigate\udthe in vitro inhibition of α-amylase and α-glucosidase by extracts of N. tabacum\udleaf. Powdered leaves were extracted with acetone, ethanol and water, and\udtested for their ability to inhibit α-amylase from Aspergilus oryzae and α-\udglucosidase from Saccharomyces cerevisae. The results revealed that aqueous\udextract of the plant was most effective inhibitor of α-amylase (IC50 5.70 mg/\udmL) while acetone extract exhibited the best inhibitory potential on α-\udglucosidase (IC50 4.50 mg/mL). Kinetic studies showed that the mode of\udinhibition of α-amylase by aqueous extract was non-competitive while that of\udthe acetone extract on α-glucosidase was competitive. The observed\udinhibitions of α-amylase and α-glucosidase suggest that the leaf extracts of N.\udtabacum may be useful in the management of Diabetes mellitus, which may\uddue to the presence of phytochemicals

<i>In vitro</l> study on the hypoglycemic potential of <i>Nicotiana tabacum</i> leaf extracts