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The methanol extract of the root of Aegle marmelos, a medicinal plant, was frac- tionated into eight fractions using column chromatography. The antidiabetic activity of all the fractions was studied using the glucose uptake by isolated rat hemi-diaphragm in vitro model. Using the bioassay-guided fractionation, two compounds 1 and 2 were isolated by column chromatography and identi- fied as 6-methyl-4-chromanone and skimmianine respectively by NMR and mass spectral methods.

In vitro glucose uptake by isolated rat hemi-diaphragm study of Aegle marmelos Correa root