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Background: Postpartum hemorrhage is the leading cause of maternal mortality; uterine atony is the most important cause. Uterotonics are used to prevent uterine atony. Carbetocin, a synthetic anallague of oxytocin seems to be an effective and safe new drug for prevention of PPH after caesarean The Aim of Study: To find out the efficacy and safety of carbetocin over oxytocin for the prevention of PPH during caesarean section. Patients and Methods: A randomized-controlled trial was conducted in the Dept. of Obs & Gyane, Rangpur Medical College and Hospital, Rangpur, Bangladesh over a period of twelve months from June 2016 to June 2017. One hundred admitted patients undergoing cesarean section at term were randomized into two groups receiving either 10 IU oxytocin or 100 μg carbetocin after caesarean section. Outcome measures such as primary PPH, massive blood loss, need for additional uterotonic drug, additional blood transfusion as well as adverse effects were all documented. Results: Massive blood loss occurred in 6% patients, blood transfusion needed in 20% patients and additional uterotonic needed for 36% patients in Oxytocin group but in Carbetocin group no massive blood lossoccurred, only 2%patients needed immediate blood transfusion and 4% patients were required additional uterotonics. There were no major adverse effects observed in both the groups. No patients had developed PPH in carbetocin group. But 8%(4) patients had developed PPH in oxytocin group. Conclusion: Carbetocin appears to be an effective new drug than Oxytocin for the prevention of postpartum hemorrhage following caesarean section.

Carbetocin Versus Oxytocin for Prophylaxis of PPH Used During Caesarean Section: An Open Label Randomized Control Trial