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Background: The biofilm production is an important phenomenon by bacteria such as Staphylococcus aureus  that contribute to the multiple drug resistance. Moreover, biofilm formation by multidrug-resistant  Staphylococcus aureus causes evading from immune responses. Objective: The aim of this study was to detect  biofilm formation and presence of several related genes among multidrug-resistant (MDR) isolates of  Staphylococcus aureus . Methods: This cross sectional study was conducted at a hospital in Tehran, Iran from  July 2012 to January 2013. Patients admitted with the infections of the different sites of the body were selected  as study population. Staphylococcus aureus isolates were collected from hospitalized patients and identified by  conventional diagnostic tests. The multidrug-resistant MRSA isolates were detected by antibiotic susceptibility  test. The phenotypic biofilm formation was detected by micro-titre tissue plate assay. The polymerase chain  reaction (PCR) was performed to detect the mecA , Staphylococcal Cassette Chromosome mec (SCC mec ) types,  accessory gene regulatory ( agr ) genes, the icaADBC and several genes encoding staphylococcal surface  proteins including clfAB, fnbAB, fib, eno, can, ebps and bbp genes with specific primers. Results: A total  number of 209 Staphylococcus aureus were isolated of which 64 (30.6%) isolates were methicillin-resistant;  among which 36(56.2%) isolates were MDR. These isolates were resistant to amoxicillin, tetracycline,  ciprofloxacin, gentamicin, erythromycin and trimethoprim-sulfamethoxazole. All the isolates were susceptible  to vancomycin and linezolid. All the MDR-MRSA harbored SCC mec type III. All the MDR- MRSA isolates  were strong biofilm producers in the phenotypic test. Conclusions: Multidrug-resistant MRSA isolates  produced biofilm strongly and the majority of these isolates harbored most of biofilm related genes. Bangladesh Journal of Infectious Diseases 2014;1(2):27-31

Biofilm Formation in Multi-Drug Resistant Staphylococcus Aureus Isolates from Hospitalized Patients