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1. Associate Professor, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. 2. Specialist, Department of Neonatology, United Hospital Ltd. Gulshan, Dhaka. 3. Medical Officer, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. 4. Professor, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Correspondence: Dr. Sanjoy Kumer Dey, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. E-mail: skdey19@gmail.com Introduction Hyperbilirubinemia is one of the most common neonatal morbidity requiring admission and intervention in majority of the newborns. Haemolytic disease of newborn (HDN) is one of the important cause of hyperbilirubinemia for which evaluation is mandatory. It is defined as incompatibility between maternal and infant blood resulting in the fetal red cell destruction and hyperbilirubinemia in the neonatal period.1 ABO and Rh incompatibility are the most common cause of clinically significant and serious indirect hyperbilirubinemia. Minor blood group incompatibilities (such as anti-Kell, anti-C, anti-E) are held responsible for 3-5% of all newborn jaundices.2-4 These haemolytic diseases are caused by destruction of fetal and neonatal red blood cells (RBCs) through maternal alloantibody that is specific to paternally inherited red blood cell antigen.5-7 The maternal antibody passes through placenta and binds to fetal RBCs. The red blood cell (RBC) destruction process begins from inutero. It presents with a wide variety of severity, from mild anemia, reticulocytosis and neonatal hyperbilirubinemia, to marked fetal anemia and hydropic changes.8 Besides Rh and ABO isoimmunisation, recently some cases of minor blood group incompatibility are being detected due to advancement of investigation modalities. This study reports two cases of indirect hyperbilirubinemia due to minor blood group incompatibility in newborns of previously transfused mothers, which will help to think about these minor groups.

Neonatal Hyperbilirubinemia associated with Minor Blood Group Incompatibility: Two Case Reports