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The paper presents data regarding the status of some important bioelements that act as cofactors for different enzymes in rats with induced oxidative stress by the administration of aluminum and cisplatinum. The study was made on thirty-six Wistar albino young rats (three months old) divided randomly in four groups as follows: C – Control, 1 ml of physiologically saline (P.S); E1 – administration of 100 mg/kg bw AlCl3; E2 – administration of 10 mg/kg bw cisplatinum; E3 – administration of 100 mg/kg bw AlCl3 and 10 mg/kg bw cisplatinum. All administrations were via the intraperitoneal route (i.p.), once a week, for a four weeks period. Were measured the oxidative stress enzymes CAT (catalase), SOD (superoxide dismutase), glutathione peroxidase (GPx), Glutathione reductase (GSH-r) and the blood levels of iron, manganese, magnesium, copper, zinc, and selenium. In all experimental groups were observed the significant decrease of CAT, the significant increase of GPx and GSH-r, not significant increase of SOD, not significant fluctuations of manganese and magnesium, a significant decrease of zinc and copper and not significant decrease of selenium. We can conclude that aluminum and cisplatinum can impair the normal status of the main bioelements through induced oxidative stress.

The status of some bioelements in rats with oxidative stress induced by cisplatinum and aluminum