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The manifestation of the biological effects of nanoscale materials depends on many initial states as the NPs themselves (on their size and structural organization, on the physical nature, method of production and method of surface modification), and on the biological model under test and the following interfaces “nano-bio” after penetration into tissues and blood, so they are not predictable, and target organs and mechanisms of development of toxic effect can be varied, which is the basis for urgent need to improve scientific approaches to the assessment of toxicity and danger of nanomaterials.

Peculiarities of safety assessment of nanoscale materials (literature review)