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Several drugs have been prepared to evaluate their interaction with coronavirus disease (COVID-19) using some docking models. The aim of this research was to prepare five cyclobuta-1,3dien-1-yl-steroid derivatives from 3-ethylinaniline using some chemical reactions. In addition, the interaction of compounds 3 to 7 with COVID-19 (6LU7 protein) was evaluated using chloroquine, remdesivir, and favipiravir as controls in a theoretical model. The results showed that compounds 6 have a higher affinity by 6LU7-protein surface compared with either chloroquine, remdesivir, and favipiravir. In addition, remdesivir have lower affinity by 6LU7-protein in comparison with compound 5. In conclusion, this phenomenon suggests that either compounds 5 or 6 could exert some changes in the biological activity of COVID-19.

Design and Synthesis of Five Cyclobuta-1,3-Dien-1-yl-Steroid Derivatives to Evaluate Their Theoretical Activity Against COVID-19