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Lupeol, is naturally occurring compound present in plants, with some beneficial health effects. In the present study, organogel-based emulsions (o/w) were obtained from canola oil. Particle size analysis, rheology test, optical microscopy, and permeability of nutraceuticals by cell culture and UPLC-MS/MS were done. Particle hydrodynamic diameters obtained in organogel-based emulsions loaded with nutraceuticals were <200nm, Polydispersity Index (PdI) was around 0.25-0.4, and Zeta Potential (ZP) was about -19 to 25mV. Droplets in emulsions presented spherical shapes and adjusted to the Herschel-Bulkley model. Interestingly, permeability of lupeol was increased compared with its crystalline; therefore organogel-based emulsions loaded with lupeol have potential for controlled delivery of this nutraceutical.

Physical characterization and permeability of lupeol by use of organogel-based emulsions (o/w)