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To address the problem of estimating disease frequency identified by a diagnostic test, which may not represent the actual number of persons with disease in a community, but rather the number of persons who tested positive. Those two values may be very different, their relationship depending on the properties of the diagnostic test applied and true prevalence of the disease in a population.

Reducing Bias from Test Misclassification in Burden of Disease Studies: Use of Test to Actual Positive Ratio – New Test Parameter