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Induced pluripotent stem cells (iPSC) could differentiate into different cells including hematopoietic stem and progenitor cells (HSPC).[1][1],[2][2] However, in vitro generation of transplantable HSPC from iPSC is still challenging.[2][2],[3][3] Recent studies reported that engraftable HSPC could

haematologica

<i>In vivo</i> generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A

In vivo generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A