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Myeloablative hematopoietic cell transplantation (HCT) reduces relapse, but is precluded in older patients and those with high comorbidities in whom outcomes remain disappointing. After demonstrating the safety of timed-sequential administration of myeloablative busulfan with fludarabine (Bu-Flu) in

haematologica

Myeloablative conditioning using timed-sequential busulfan plus fludarabine in older patients with acute myeloid leukemia: long-term results of a prospective phase II clinical trial