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Current treatments for chronic lymphocytic leukemia (CLL) include targeted therapies like ibrutinib and monoclonal antibodies (rituximab and obinutuzumab). Although obinutuzumab shows better antitumor activity than rituximab, it induces more frequent and more severe infusion-related reactions (IRR

haematologica

Ibrutinib reduces obinutuzumab infusion-related reactions in patients with chronic lymphocytic leukemia and is associated with changes in plasma cytokine levels