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The genetic hallmark of Burkitt lymphoma (BL) is a translocation juxtaposing the MYC-oncogene to one of the three immunoglobulin (IG) loci.[1][1] There is ongoing controversy whether IG- MYC negative “true” BL exist. Various studies have identified 2-22% of BL as “ MYC -negative”.[2][2]–[5

haematologica

Cryptic insertion of <i>MYC</i> exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of “<i>MYC</i>-negative” Burkitt lymphoma

Cryptic insertion of MYC exons 2 and 3 into the immunoglobulin heavy chain locus detected by whole genome sequencing in a case of “MYC-negative” Burkitt lymphoma