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The single catastrophic event chromothripsis, initially uncovered in a case of chronic lymphocytic leukemia by whole genome sequencing,[1][1] is a novel phenomenon of genomic instability. It is characterized by extensive genomic rearrangements reflected by an oscillating pattern of DNA copy-number

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype