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Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation,

Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells