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Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. In recent years, it has become apparent that CLL is strongly dependent on its microenvironment for survival and proliferation. The pro-survival effect of the micro-environment is mainly mediated by upregulation of anti-

Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA