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Signal Transducer and Activator of Transcription 3 (STAT3) responses to ligands correlate with outcome in pediatric acute myeloid leukemia (AML),[1][1] suggesting a possible relationship between chemotherapy response and the STAT3 pathway. We hypothesized that consistently altered changes in STAT3

haematologica

Ligand-induced STAT3 signaling increases at relapse and is associated with outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group