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The presence of sickle hemoglobin (HbS) in red blood cells (RBC) of patients with sickle cell anemia (SCA) is at the origin of their rheological abnormalities. Abnormal blood rheology has been shown to modulate the clinical severity and to also be involved in several complications of SCA.[1][1]–[3

Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia