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Pre-transplant myeloablation increases bone marrow (BM) adipogenesis and destroys the niche cells, adversely affecting the hematopoietic stem cell (HSC) engraftment. This becomes a serious issue when donor HSCs are few or if their functionality is compromised. Therapeutic targeting of the niche[1][1

Simvastatin improves hematopoietic stem cell engraftment by preventing irradiation-induced marrow adipogenesis and radio-protecting the niche cells