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Gamma heavy chain disease (gHCD) is defined by an abnormally truncated IgG heavy chain monoclonal protein that lacks associated light chains and is secreted by a small B-cell neoplasm with plasmacytic differentiation.[1][1],[2][2] Clinically, gHCD is associated with a female predominance and a high

Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma