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In the acute myeloid leukemia (AML)-associated chromosomal translocation t(8;21), the hematopoietic master regulator RUNX1 (also known as AML1 , CBF α 2 or PEBP2 α B ) located on chromosome 21 is fused to almost the entire ETO gene (also known as MTG8 or RUNX1T1 ) on chromosome 8, thereby

The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells