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The main side-effect of transfusion is alloimunization against red blood cell (RBC) antigens. Thirteen percent of the general population were shown to be responders and 30% of responders make antibodies indicating a rate of alloimmunization of 3.9%.[1][1] However, alloimmunization is more frequent

Red blood cell immunization in sickle cell disease: evidence of a large responder group and a low rate of anti-Rh linked to partial Rh phenotype