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In the May issue of Haematologica, Foa et al.1 provided a comprehensive and authoritative review of the impact of the new sequencing technologies on the clinical management of patients with chronic lymphocytic leukemia. We thoroughly enjoyed studying the review and would like to comment only on a technical point, which is nevertheless of great importance in the field of hematopathology.

Archival bone marrow trephines are suitable for high-throughput mutation analysis using next generation sequencing technology