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The 46/1 haplotype of chromosome 9p, present in about 45% of the general population, is associated with a predisposition to mutations in the Janus Kinase 2 ( JAK2 ) gene on the same allele and to chronic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia and primary

haematologica

The JAK2 46/1 haplotype: a marker of inappropriate myelomonocytic response to cytokine stimulation, leading to increased risk of inflammation, myeloid neoplasm, and impaired defense against infection?