Open AccessMulticenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study
Author(s) -
Matteo Giovanni Della Porta,
Cristina Picone,
Cristiana Pascutto,
Luca Malcovati,
Hideto Tamura,
Hiroshi Handa,
Magdalena Czader,
Sylvie Freeman,
Paresh Vyas,
Anna Porwit,
Leonie Saft,
Theresia M. Westers,
Canan Alhan,
Claudia Cali,
Arjan A. van de Loosdrecht,
K. Ogata
Publication year - 2012
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2011.048421
Subject(s) - myelodysplastic syndromes , medicine , dysplasia , cd34 , bone marrow , oncology , cohort , international prognostic scoring system , pathology , stem cell , genetics , biology
The current World Health Organization classification of myelodysplastic syndromes is based morphological evaluation of bone marrow dysplasia. In clinical practice, the reproducibility of the recognition of dysplasia is usually poor especially in cases that lack specific markers such as ring sideroblasts and clonal cytogenetic abnormalities.
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