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KANK1-PDGFRB is a fusion gene generated by the t(5;9) translocation between KANK1 and the platelet-derived growth factor receptor beta gene PDGFRB. This hybrid was identified in a myeloproliferative neoplasm featuring severe thrombocythemia, in the absence of the JAK2 V617F mutation.

Multiple oligomerization domains of KANK1-PDGFR are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK