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Mantle cell lymphoma (MCL) and multiple myeloma (MM) are aggressive hemopathies characterized by the presence of the cyclin D1 protein in 100% and 50% of the cases, respectively. The presence of cyclin D1, which is not expressed along the B-cell lineage, is causal in MCL and MM pathogenesis. It is

The targeting of the sole cyclin D1 is not adequate for mantle cell lymphoma and myeloma therapies