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Imatinib, a targeted inhibitor of the tyrosine kinase activity of the BCR-ABL oncoprotein, has demonstrated considerable efficacy in all phases of chronic myeloid leukemia (CML). [1][1] Recently, Palandri and colleagues reported on the long-term outcomes of patients with CML in accelerated phase[2][

haematologica

Sustained durability of responses and improved progression-free and overall survival with imatinib treatment for accelerated phase and blast crisis chronic myeloid leukemia: long-term follow-up of the STI571 0102 and 0109 trials