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The vaso-occlusive process in sickle cell disease is responsible for much of the morbidity and mortality observed in this condition, and adhesion molecules play a crucial role in it. Hydroxyurea treatment has proven clinical benefit in sickle cell disease, and Drs. Johnson and Telen discuss how this drug may affect the adhesive interactions between blood cells and the endothelium leading to vaso-occlusion. See related article on page 502.

Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease