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Mantle cell lymphoma (MCL) is a B-cell lymphoproliferative disorder which predominantly affects men. In a large retrospective survey of the European MCL Network including 304 patients, median age was 63 years at first diagnosis with a male preponderance of 76%.[1][1] The genetic hallmark of MCL is

haematologica

Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma