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Chromosomal translocations involving the immunoglobulin genes ( IG ) are common in malignant lymphomas.[1][1],[2][2] The t(14;18)(q32;q21), which juxtaposes the BCL-2 gene, normally located at 18q21, with the IG heavy-chain locus on 14q32, is the genetic hallmark of follicular lymphoma (FL).

haematologica

High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis