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In a preceding paper, we showed that aroma candy containing oligonol, capric acid, and cinnamon (cassia) powder had potent inhibitory activity against mycelial growth of Candida albicans in vitro and protective activity against murine oral candidiasis. In order to assess the effects of this candy (the test candy) on oral C. albicans colony-forming units (CFU) and oral hygiene states, a placebo-controlled double-blind crossover comparative study was performed. Twenty subjects were divided into two groups. One group ingested the test candy in the first 7 days followed by 2 weeks washing-off period, then ingested the placebo candy (control candy) for 7 days. The other group was vice versa. C. albicans CFU in all oral rinse samples from the subjects before and after 7 days ingestion of candy was measured. The degree of oral malodor in all subjects was monitored using a portable measuring instrument. The results showed no statistically significant difference between test-candy group and placebo group for C. albicans CFU. However, C. albicans CFU in test-candy group with&gt;4,000 CFUs was significantly decreased after 7 days ingestion of test-candy (p&lt;0.05). Scores of oral malodor in the test-candy group was significantly decreased after 7 days ingestion of test-candy (p&lt;0.05). A questionnaire survey of oral hygiene states indicated that in the test-candy group, oral malodor, glutinous feeling, and refreshing feeling significantly improved in comparison with control-candy group (p&lt;0.05). Our study suggests that the aroma candy is effective in oral health care of elderly carrying C. albicans.

medical mycology journal

The Effects of an Aroma Candy on Oral &lt;I&gt;Candida albicans&lt;/I&gt; Colony-forming Units (CFU) and Oral Hygiene States in Healthy Elderly Carrying &lt;I&gt;Candida albicans&lt;/I&gt;