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Instant chocolate drinks,  as  immunomodulator  drinks,  were  developed from the instant chocolate - ginger drink of Rosniati, as a functional drink (2011). Drinks were  formulated from  55 % sucrose, 30 %  cocoa  powder (processed from non – fermented and non roasted cocoa beans), and 15 % non – dairy creamer, in (w/w), as A formula, and the other from 55 % sucrose, 30 % cocoa  powder (processd from non – fermented and non – roasted cocoa beans), and 15 % instant soy powder, in (w/w), as B formula. Preparation of drinks also used co-crystallization technique. Of the two formulas, the B formula (combination of cocoa powder and instant soy powder), in the in-vivo tests, showed better in immunomodulation effects. Indeed, at a dose of 39 (mg/kg of mice weight), the B formula had non specific immune response with phagocytic index of 2.042 (strong), primary antibody titer of 1 : 384 and secondary antibody titer of 1 : 768, as humoral immune response, and IFN- γ of 1,436,360.14 (pmol) and IL-2 of 941.30 (pmol), as cellular immune response, all above the control drink values. Key words: instant chocolate drink, immunomodulator, non-fermented, non-roasted cocoa beans, instant soy powder . Abs t r a k . Minuman instan cokelat sebagai minuman imunomodulator, dikembangkan dari m i numan cokelat-jahe instan dari Rosniati, sebagai minuman fungsional (2011). Minuman imunomodulator diformulasi dari bubuk kakao 30% (diolah dari biji kakao t anpa fermentasi dan tanpa sangrai), gula sukrosa 55%, dan non-dairy creamer 15% (b /b ) , sebagai formula A, dan dari bubuk kakao 30% (diolah dari biji kakao tanpa f er m e n t a s i dan tanpa sangrai, gula sukrosa 55%, dan bubuk kedelai instan15% (b/b), se b a g a i formula B. Penyiapan produk minuman ini juga menggunakan teknik ko- kr i s t a l i s a s i . Dari kedua formula minuman imunomodukator, formula B (kombinasi bubuk kak a o dengan bubuk instan kedelai) memberikan efek imunomodulasi yang lebih tinggi. B a h kan pada pemberian dosis 39 (mg/kg berat mencit), secara in vivo, menghasilkan re s po n imun non spesifik dengan indeks fagositik 2,042 (kuat), titer antibodi primer 1: 3 8 4 dan titer antibodi sekunder 1:768, sebagai respon imun humoral, dan IFN-γ se b e sa r .43 6 . 60, 1 4 (pmol) dan IL-2 sebesar 941,30 (pmol), sebagai respon imun selular, yang semuanya berada diatas nilai kontrol. Kata kunci: minuman cokelat instan, imunomodulator, biji kakao tanpa fermentasi dan t anpa sangrai, bubuk kedelai instan.

FORMULASI MINUMAN INSTAN COKELAT SEBAGAI MINUMAN IMUNOMODULATOR. (Formulation of Instant Chocolate Drinks as Immunomodulator Drinks)