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1Pain Research Institute, Clinical Sciences Centre, Liverpool, UK 2King’s Clinical Trials Unit, Institute of Psychiatry, Psychology and Neuroscience, London, UK 3Pain Management and Neuromodulation Centre, Guy’s and St Thomas’ Hospital, London, UK 4The Walton Centre NHS Foundation Trust, Liverpool, UK 5Modepharma Ltd, Beckenham, UK 6University Department of Anaesthesia, Queen Elizabeth University Hospital, Glasgow Clinical Research Facility, Glasgow, UK, 7Royal National Hospital for Rheumatic Diseases, Bath, UK 8University of the West of England, Bristol, UK 9College of Human and Health Sciences, Swansea University, Swansea, UK 10Faculty of Science, Liverpool John Moores University, Liverpool, UK 11Norfolk and Norwich University NHS Trust, Norwich, UK 12Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK, 13University Hospital of Leicester NHS Trust, Leicester General Hospital, Leicester, UK 14Statistical Science, University College London, London, UK

efficacy and mechanism evaluation

A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)