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1National Heart and Lung Institute, Imperial College London, London, UK 2Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK 3Institute for Lung Health, University of Leicester, Leicester, UK 4Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK 5Respiratory Medicine, NHS Greater Glasgow and Clyde, Glasgow, UK 6Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, UK 7Respiratory Medicine, Heart of England NHS Foundation Trust, Birmingham, UK 8Severe and Brittle Asthma Unit, University of Birmingham, Birmingham, UK 9Department of Respiratory Medicine and Allergy, School of Medicine, King’s College London, London, UK 10Department of Asthma, Allergy and Respiratory Science, Guy’s and St Thomas’ NHS Foundation Trust, London, UK 11Respiratory Medicine, Newcastle University, Newcastle, UK 12Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK 13Medicines Evaluation Unit (MEU), University of Manchester, Manchester, UK 14Respiratory Medicine, Portsmouth Hospitals NHS Trust, Portsmouth, UK

efficacy and mechanism evaluation

A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin as a supplement to standard care for adult patients with acute exacerbations of asthma (the AZALEA trial)