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A free radical is a relatively unstable molecule with an atom in its outer orbit having one or more unpaired electrons. The molecule that loses the pair becomes unstable and radical. Therefore, this molecule always tries to find its electron pair by seizing electrons from other molecules1,2. Free radicals can damage collagen and elastin, which are a protein that keeps skin moisturized, smooth, flexible, and elastic. Excessive free radical levels trigger various degenerative diseases and conditions in the skin, such as premature aging, wrinkles, erythema, skin cancer, and others3,4. Aging is a process that is a certainty, but premature aging is something that is not expected. The skin's premature aging is characterized by thinning skin, dry skin, wrinkles, and uneven coloration5. One of the causes of premature aging is free radical6. One of the ways used to prevent premature aging is to use cosmetics that contain antioxidants. These antioxidants can inhibit the development of oxidation reactions by binding to free radicals and highly reactive molecules to inhibit cell damage7. One of the cosmetic dosage forms that have developed lately to prevent premature aging is serum. The serum has the advantage of having a high concentration of active ingredients so that the skin more quickly absorbs the effect, can provide a more relaxing effect, and is easier to spread on the surface of the skin because the viscosity is not too high8. Research on antioxidant activity from medicinal plants in serum form has been carried out, including by Mardhiani The Combination of Turmeric (Curcuma domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant