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Rational drug use (RDU) is the use of drugs that are in accordance with the criteria, such as the right medicine, the right diagnosis, the right indication, how to use it, the time of administration, the right condition of the patient, timely administration and alert to side effects (Smeulers et al., 2015). World Health Organization (WHO) estimates that almost more than half of all drugs in the world are given, sold and prescribed inappropriately, and half of the patient’s misuse drugs (Ministry of Health of the Republic of Indonesia, 2017). Where it is known that irrational use of drugs, as well as negative impacts, is greater than the benefits, received by patients, side effects and antibiotic resistance occur, besides the costs are not affordable/too expensive (Ofori-Asenso & Agyeman, 2016). Medication prescription is usually done as the last step in patient and doctor consultation, but there are still frequent therapeutic errors (medication errors)/therapy (FitzGerald, 2009). This error usually occurs in prescribing, where when choosing the type of drug, dosage, how to use it, writing is challenging to read, where the incident becomes a supporting factor in increasing therapeutic errors (Simatupang, 2012). Rational Drug Use is one of the things that needs to be done to get maximum treatment (Basaran & Akici, 2012). Evaluation of RDU is reviewed from prescription based on disease, according to Ministry of Health of the Republic of Indonesia (2017), which has been listed using Evaluation of Rational Drug Use based on Indicators of Diseases and Facilities at Community Health Centers in Districts in Semarang