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A variety of epidemiological and genetic studies have revealed that disturbances of circadian rhythms can be directly linked to the risk of cancer development [1,2]. This is because cell cycle regulators, which are essential for cell proliferation and at the same time closely associated with tumor production, are under the control of the circadian clock. Interestingly, in the case of rapidly dividing cells, such as tumor cells or stem cells, the expression of the biological clock genes is significantly suppressed. This early study results have raised the possibility that the activation of the circadian biological clock plays a key role in tumor production and its treatment. In particular, since the study of the biological clock was conducted in earnest, it has been known that the efficacy of anticancer drugs can be maximized and the side effects on normal cells Comparison of Morning and Evening/Night Dosing on the Efficacy of Escitalopram in Major Depressive Disorder at Naturalistic Setting