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Bipolar disorder (BD) is a common mental disorder characterized by episodic mood symptoms, including episodes of mania or hypomania and depression, and its mood episodes are severe and lifelong [1,2]. The lifetime prevalence of BD is approximately 3.9–6.4% in the general population [3-5], and the lifetime prevalence of bipolar I disorder (BID) is between 1% and 2% [6,7]. Relapse and recurrence are very common and the lifetime risk of suicide is as high as 20% in BD patients, resulting in serious economic costs [8]. The representative defining character of BD is the development of alternating episodes of mania, hypomania, or depression [6]. All BD episode types typically show prominent sleep disturbance. Usually, the necessity for sleep is reduced during mania or hypoA Genome-Wide Association Study of Bipolar Disorder Using a Subphenotype: Sleeplessness Symptom of Bipolar Mania