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Introduccion: la matriz extracelular (MEC) es una red multifuncional, dinamica y compleja con propiedades biofisicas, mecanicas y bioquimicas especificas para cada tejido que, le confieren la capacidad de regular el comportamiento celular. Las celulas madre tienen un papel clave en el mantenimiento y regeneracion tisular, se hallan en  un microambiente especifico, definido como nicho, en el que la MEC puede modular su proliferacion, autorenovacion y diferenciacion. Objetivo: resaltar la funcion de la MEC en la regulacion del comportamiento de las celulas madre y la labor de la interaccion MEC-celulas madre en las propiedades y homeostasis del nicho en el que residen. Materiales y metodos: busqueda electronica en las bases de datos: PubMed, ScienceDirect, Scopus y Medline de articulos originales y de revision en su mayor parte publicados entre 2008 y 2015. Resultados: se obtuvieron 150 articulos, de los que se utilizaron 44 documentos a conveniencia incluyendo articulos de revision y articulos originales. Conclusion: la MEC es una red fundamental que orienta la diferenciacion, proliferacion y autorenovacion de las celulas madre, al tiempo que ejerce una interaccion de estas con los nichos donde residen. La funcion esencial de la MEC en la interrelacion de las celulas madre con su nicho ha llevado al surgimiento de herramientas de la bioingenieria que abren posibilidades en la terapeutica, reparacion y regeneracion fisiologica de organos. Rev.cienc.biomed. 2015;6(2):333-339 PALABRAS CLAVE Matriz extracelular; Celulas madre; Nicho de celulas madre; Bioingenieria; Celulas madre hematopoyeticas. SUMMARY Introduction: extracellular matrix (ECM) is a multifunctional network, dynamic and complex with specific biophysics, mechanic, and biochemical properties for each tissue, which function is to regulate the cellular behavior. Stem cells play an important role in the tissue maintenance and regeneration and they are found in a specific microenvironment, defined as niche, in which the ECM can modulate the proliferation, self-renewal and differentiation. Objective: to highlight the function of the ECM in regulating the stem cells behavior and the labor of the ECM-stem cell interaction in the properties and homeostasis of the niche in which they reside. Material and methods: electronic search in the databases: PubMed, ScienceDirect, Scopus and Medline of review and original articles mostly published between 2008 and2015. Results: 150 articles were obtained, from which 44 documents were used for convenience including review articles and original articles. Conclusion: ECM is a fundamental network that guides the differentiation, proliferation and self-renewal of stem cells, while exerting interaction of these cells with the niches where they reside. The key role of ECM in the interrelation of stem cells with their niche has led to the emergence of bioengineering tools that open up possibilities in the therapy, repair and physiological regeneration of organs. Rev.cienc.biomed.2015;6(2):333-339 KEYWORDS Extracellular matrix; Stem cell; Stem cell niche; Bioengineering; Hematopoietic stemcells.

La matriz extracelular: una red dinámica implicada en la regulación de las células madre