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Background Lu and Sm are perspective radionuclides in terms of applying to nuclear medicine. High-energy beta particles and the relative half-life of the radionuclide are used to achieve an effective palliative treatment of bone metastases. Materials and methods The absorbed doses in different organs and tissues of Lu and Sm in ionic form and labeled with EDTMP are determined by IDAC-Dose 2.1 (Internal Dose Assessment by Computer) software and WinAct software which used to calculate cumulative activity. Lu and Sm are lanthanide radionuclide which actively accumulates in liver and bone when used in ionic form. In the case of labeling with EDTMP, the distribution and elimination of the drug occur according to the kinetics of a carrier, EDTMP. The using of osteotropic (Describing any drug etc. that is attracted to, and targets bone) complex allows creating a large dose in the pathological areas and minimizing damages in healthy organs and tissues. Results The effective dose per administered activity is 0.189 mSv/MBq for Lu-ionic form, 0.232 mSv/MBq for Sm-ionic form and 0.242 mSv/MBq for Lu-EDTMP and 0.139 mSv/MBq for sm-EDTMP. Conclusion Lu and Sm labeled with EDTMP are decreasing the liver dose absorption and increasing the bone surface absorption for more effective treatment and minimize side effects.

Labeling of ethylenediamine tetramethylene phosphonate with 153Sm and 177Lu,Comparison Study