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The study aimed at evaluating the frequency of HPV in breast cancer women in relation with serum IL-8 level. The study that carried out in Kirkuk city from 15 th of January 2017 to 15 th of June 2017, a total of 150 breast cancer women who admitted to Kirkuk oncology cancer and 96 healthy control women whose ages were between 30-75 years. Patients and control were investigated for detection of human papilloma virus (HPV) 16 E7 protein and interleukin-8 (IL-8) by ELISA technique. The rate of breast cancer women with HPV 16 E7 (30.67%) was higher than that in control women (3.125%) with highly significant relation. The highest rate of breast cancer women was within the age group 40-49 years with no significant relation between breast cancer and age. The study showed that the highest means of IL-8 level (36.92 pg/ml) were found in breast cancer women without HPV, 29.09 pg/ml in HPV positive and 6.45 pg/ml in the control group with highly significant relation. There was a highly significant relation of WBCs, lymphocytes and neutrophils count and Hb level among the study groups concerning HPV. WBCs count and hemoglobin level were higher in the control group than in breast cancer women. The mean absolute lymphocytes count was higher in breast cancer women with HPV infection than those without HPV and the control group (4.13, 1.80 and 1.89 respectively), while the least mean of neutrophils count was reported in breast cancer women with HPV infection. Conclusions: It was concluded that there was a highly significant relation between HPV and EBV infection with breast cancer.

The Prevalence of Human Papilloma Virus among Breast Cancer Women in Relation with IL-8 Level in Kirkuk Province